On REYATAZ, how you spend your time is up to you. Individual results may vary.

How to Take REYATAZ

The usual REYATAZ dosage for most people is one or two REYATAZ capsules (see bullets below) once daily. REYATAZ must always be taken with a meal or snack and in combination with other HIV medications. Your healthcare provider will let you know the REYATAZ dosage that is right for you.

Do not take REYATAZ if you are allergic to REYATAZ or to any of its ingredients.

Read more REYATAZ Important Safety Information.

General Directions for taking once-daily REYATAZ. Follow the guidelines below to take REYATAZ correctly:

  • Take REYATAZ once every day exactly as instructed by your healthcare provider. Your healthcare provider will prescribe the amount of REYATAZ® (atazanavir sulfate) that is right for you:
    • For adults who have never taken anti-HIV medicines before, the dose is 300 mg once daily with 100 mg of Norvir® (ritonavir) once daily taken with food. For adults who are unable to tolerate ritonavir, 400 mg (two 200-mg capsules) once daily (without Norvir®) taken with food is recommended.
    • For adults who have taken anti-HIV medicines in the past, the usual dose is 300 mg plus 100 mg of Norvir® (ritonavir) once daily taken with food.
    • Pregnancy: REYATAZ 300mg with ritonavir 100 mg once daily with food, with dosing modifications if used with certain other medicines.
    • Dosing recommendations are available for children 6 years of age or older for REYATAZ capsules. Dosing recommendations are not available for children from 3 months to less than 6 years of age. REYATAZ should not be used in babies under the age of 3 months.
  • Your dose will depend on your liver function and on the other anti-HIV medicines that you are taking. REYATAZ is always used with other anti-HIV medicines. If you are taking REYATAZ with Sustiva® (efavirenz) or with
    Viread® (tenofovir disoproxil fumarate), you should also be taking Norvir® (ritonavir).
  • Always take REYATAZ with food (a meal or snack) to help it work better. Swallow the capsules whole. Do not open the capsules. Take REYATAZ at the same time each day.
  • If you are taking antacids or didanosine (Videx® or Videx® EC), take REYATAZ 2 hours before or 1 hour after these medicines.
  • If you are taking medicines for indigestion, heartburn, or ulcers such as Axid® (nizatidine), Pepcid AC® (famotidine), Tagamet® (cimetidine), Zantac® (ranitidine), AcipHex® (rabeprazole), Nexium® (esomeprazole), Prevacid® (lansoprazole), Prilosec® (omeprazole), or Protonix® (pantoprazole), talk to your healthcare provider.
  • Do not change your dose or stop taking REYATAZ without first talking with your healthcare provider. It is important to stay under a healthcare provider’s care while taking REYATAZ.
  • When your supply of REYATAZ starts to run low, get more from your healthcare provider or pharmacy. It is important not to run out of REYATAZ. The amount of HIV in your blood may increase if the medicine is stopped for even a short time.
  • If you miss a dose of REYATAZ, take it as soon as possible and then take your next scheduled dose at its regular time. If, however, it is within 6 hours of your next dose, do not take the missed dose. Wait and take the next dose at the regular time. Do not double the next dose. It is important that you do not miss any doses of REYATAZ or your other anti-HIV medicines.
  • If you take more than the prescribed dose of
    REYATAZ® (atazanavir sulfate)
    , call your healthcare provider or poison control center right away.

The importance of taking HIV medications regularly

If you don’t take your REYATAZ and other HIV medications every day as directed by your healthcare provider, they may not work effectively. That could lead to an increase in your HIV viral load and decrease your CD4+ cell count, both of which can increase your chances of becoming sick.

Another reason to take your REYATAZ and other HIV medications correctly is that HIV can become resistant to the drugs used to treat it. If the level of an HIV medication in your body drops too low, then it can’t effectively prevent HIV from reproducing. This gives the virus a chance to become resistant to that medication and possibly other medications like it.

Setting up and following a regular schedule can help you to remember to take your REYATAZ and other HIV medications once a day. Work with your healthcare provider to set up a treatment regimen that works for you.

To increase your chances of staying on schedule with REYATAZ, try the following:

  • Take REYATAZ at the same time every day with a meal or a snack. If you decide to take REYATAZ with breakfast, lunch or dinner, you are more likely to keep taking it at the same time every day. You can also take REYATAZ with a light snack. Taking REYATAZ with a meal or snack helps it work better.
  • Always carry an extra dose or two, in case you’re unexpectedly away from home when it’s time to take your medicine.
  • When you travel, pack your medicine in your carry-on luggage.
  • Always refill prescriptions before you run out of REYATAZ. When your supply of REYATAZ starts to run low, it’s time to call your healthcare provider or pharmacy for a refill.

It is worth repeating: It is important that you do not miss any doses of REYATAZ or your other HIV medications.

Selected Important Safety Information

About REYATAZ® (atazanavir sulfate)

Tell your healthcare provider right away if you have any side effects, symptoms, or conditions, including the following:

  • Mild rash (redness and itching) without other symptoms sometimes occurs in patients taking REYATAZ® (atazanavir sulfate), most often in the first few weeks after the medicine is started, and usually goes away within 2 weeks with no change in treatment.
  • Severe rash may develop with other symptoms that could be serious and potentially cause death. If you develop a rash with any of the following symptoms, stop using REYATAZ and call your healthcare provider
    right away:
    • - Shortness of breath
    • - General ill-feeling or "flu-like" symptoms
    • - Fever
    • - Muscle or joint aches
    • - Conjunctivitis (red or inflamed eyes, like "pink-eye")
    • - Blisters
    • - Mouth sores
    • - Swelling of your face
  • Yellowing of the skin and/or eyes may occur due to increases in bilirubin levels in the blood (bilirubin is made by the liver).
  • A change in the way your heart beats may occur. You may feel dizzy or lightheaded. These could be symptoms of a heart problem.
  • Diabetes and high blood sugar may occur in patients taking protease inhibitor medicines like REYATAZ. Some patients may need changes in their diabetes medicine.
  • If you have liver disease, including hepatitis B or C, it may get worse when you take anti-HIV medicines like REYATAZ® (atazanavir sulfate).
  • Kidney stones have been reported in patients taking REYATAZ. Signs or symptoms of kidney stones include pain in your side, blood in your urine, and pain when you urinate.
  • Some patients with hemophilia have increased bleeding problems with protease inhibitor medicines like REYATAZ.
  • Changes in body fat have been seen in some patients taking anti-HIV medicines. The cause and long-term effects are not known at this time.
  • Immune reconstitution syndrome has been seen in some patients with advanced HIV infection (AIDS) and a history of opportunistic infection. Signs
    and symptoms of inflammation from previous infections may occur soon after starting anti-HIV treatment, including REYATAZ.
  • Gallbladder disorders (including gallstones and gallbladder inflammation) have been reported in patients taking REYATAZ.

Other common side effects of REYATAZ taken with other anti-HIV medicines include: nausea; headache; stomach pain; vomiting; diarrhea; depression; fever; dizziness; trouble sleeping; numbness, tingling, or burning of hands or feet; and muscle pain.

Read more REYATAZ Important Safety Information.

*"Undetectable" is defined as a viral load that is too low to be picked up by a particular test. Typically, it is a viral load of less than 400 or 50 copies/mL (depending on the test used).

Talk to your doctor

Get treatment that is right for you.


How REYATAZ fights HIV

REYATAZ is a protease inhibitor that, in combination therapy, helps prevent HIV replication. It can reduce the amount of HIV in your blood to levels that are undetectable.* REYATAZ does not cure HIV or lower your chance of passing HIV to others.


Stay Informed

Learn More about once-daily REYATAZ as part of combination therapy.